Analysis of HIF-1 inhibition by manassantin A and analogues with modified tetrahydrofuran configurations.
Kasper AC., Moon EJ., Hu X., Park Y., Wooten CM., Kim H., Yang W., Dewhirst MW., Hong J.
We have shown that manassantin A downregulated the HIF-1alpha expression and inhibited the secretion of VEGF. We have also demonstrated that the 2,3-cis-3,4-trans-4,5-cis-configuration of the tetrahydrofuran is critical to the HIF-1 inhibition of manassantin A.