Figure 3 from Small-Molecule Polθ Inhibitors Provide Safe and Effective Tumor Radiosensitization in Preclinical Models
Rodriguez-Berriguete G., Ranzani M., Prevo R., Puliyadi R., Machado N., Bolland HR., Millar V., Ebner D., Boursier M., Cerutti A., Cicconi A., Galbiati A., Grande D., Grinkevich V., Majithiya JB., Piscitello D., Rajendra E., Stockley ML., Boulton SJ., Hammond EM., Heald RA., Smith GCM., Robinson HMR., Higgins GS.
<p>ART558-mediated radiosensitization under hypoxic conditions. <b>A,</b> Clonogenic survival of H460 cells irradiated upon hypoxia (0.5% and <0.1% oxygen). For OERs, see Supplementary Fig. S4. The 6 Gy data points are replotted in a bar graph in <b>B</b> to allow better visual comparison between the different treatment arms (*, <i>P</i> < 0.05; **, <i>P</i> < 0.01; ***, <i>P</i> < 0.001; ****, <i>P</i> < 0.0001).</p>