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EMBO J 32 12: 1681–1701 doi:; DOI: 10.1038/emboj.2013.105; published online May 17 2013 How telomerase and telomeres are brought together to alleviate telomere shortening and preserve genome integrity in the cell remains incompletely understood. A study in The EMBO Journal now identifies HOT1 as a direct telomere repeat binding protein that contributes to telomerase-mediated telomere elongation, likely by bridging telomere and telomerase interactions.

Original publication

DOI

10.1038/emboj.2013.119

Type

Journal article

Journal

EMBO J

Publication Date

12/06/2013

Volume

32

Pages

1655 - 1657

Keywords

Homeodomain Proteins, Humans, Multiprotein Complexes, Telomerase, Telomere, Telomere-Binding Proteins