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This study is the first proof of concept that the FLASH effect can be triggered by X-rays. Our results show that a 10 Gy whole-brain irradiation delivered at ultra-high dose-rate with synchrotron generated X-rays does not induce memory deficit; it reduces hippocampal cell-division impairment and induces less reactive astrogliosis.

Original publication

DOI

10.1016/j.radonc.2018.08.016

Type

Journal article

Journal

Radiother Oncol

Publication Date

12/2018

Volume

129

Pages

582 - 588

Keywords

Cognitive impairment, Radiation-induced brain injury, Synchrotron radiation, Ultra-high dose-rate X-ray radiation, Animals, Brain Injuries, Cranial Irradiation, Female, Hippocampus, Memory, Mice, Mice, Inbred C57BL, Radiation Injuries, Experimental, Synchrotrons, X-Rays