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Blood lipids have been associated with the development of a range of cancers, including breast, lung and colorectal cancer. For endometrial cancer, observational studies have reported inconsistent associations between blood lipids and cancer risk. To reduce biases from unmeasured confounding, we performed a bidirectional, two-sample Mendelian randomization analysis to investigate the relationship between levels of three blood lipids (low-density lipoprotein [LDL] and high-density lipoprotein [HDL] cholesterol, and triglycerides) and endometrial cancer risk. Genetic variants associated with each of these blood lipid levels (P 

Original publication




Journal article


Int J Cancer

Publication Date





307 - 319


HDL cholesterol, LDL cholesterol, Mendelian randomization, endometrial cancer risk, triglycerides, Case-Control Studies, Cholesterol, HDL, Cholesterol, LDL, Endometrial Neoplasms, Female, Genome-Wide Association Study, Humans, Mendelian Randomization Analysis, Risk, Triglycerides