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Synthesis of the genetic material of the cell is achieved by a large number of DNA polymerases. Besides replicating the genome, they are involved in DNA-repair processes. Recent studies have indicated that certain DNA-polymerase-X-family members can synthesize unusual DNA structures, and we propose that these DNA structures might serve as 'flag wavers' for the induction of DNA-repair and/or DNA-damage-checkpoint pathways.

Original publication

DOI

10.1038/nrm1530

Type

Journal article

Journal

Nat Rev Mol Cell Biol

Publication Date

12/2004

Volume

5

Pages

1038 - 1043

Keywords

Animals, DNA, DNA Damage, DNA Repair, DNA-Directed DNA Polymerase, Humans, Models, Molecular, Multigene Family, Nucleic Acid Conformation, Protein Conformation