Mutation analysis of three genes encoding novel LKB1-interacting proteins, BRG1, STRADalpha, and MO25alpha, in Peutz-Jeghers syndrome.
Alhopuro P., Katajisto P., Lehtonen R., Ylisaukko-Oja SK., Näätsaari L., Karhu A., Westerman AM., Wilson JHP., de Rooij FWM., Vogel T., Moeslein G., Tomlinson IP., Aaltonen LA., Mäkelä TP., Launonen V.
Mutations in LKB1 lead to Peutz-Jeghers syndrome (PJS). However, only a subset of PJS patients harbours LKB1 mutations. We performed a mutation analysis of three genes encoding novel LKB1-interacting proteins, BRG1, STRADalpha, and MO25alpha, in 28 LKB1-negative PJS patients. No disease-causing mutations were detected in the studied genes in PJS patients from different European populations.