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BACKGROUND: Management of screen-detected ductal carcinoma in situ (DCIS) remains controversial. METHODS: A prospective cohort of patients with DCIS diagnosed through the UK National Health Service Breast Screening Programme (1st April 2003 to 31st March 2012) was linked to national databases and case note review to analyse patterns of care, recurrence and mortality. RESULTS: Screen-detected DCIS in 9938 women, with mean age of 60 years (range 46-87), was treated by mastectomy (2931) or breast conserving surgery (BCS) (7007; 70%). At 64 months median follow-up, 697 (6.8%) had further DCIS or invasive breast cancer after BCS (7.8%) or mastectomy (4.5%) (p 

Original publication




Journal article


Eur J Cancer

Publication Date





210 - 219


Ductal carcinoma in situ, Margins, Radiotherapy, Recurrence, Aged, Aged, 80 and over, Antineoplastic Agents, Hormonal, Breast Neoplasms, Carcinoma in Situ, Carcinoma, Ductal, Breast, Chemotherapy, Adjuvant, Combined Modality Therapy, Female, Humans, Mass Screening, Mastectomy, Mastectomy, Segmental, Middle Aged, Neoplasm Recurrence, Local, Prospective Studies, Radiotherapy, Survival Analysis, Treatment Outcome, United Kingdom