Management and 5-year outcomes in 9938 women with screen-detected ductal carcinoma in situ: the UK Sloane Project.
Thompson AM., Clements K., Cheung S., Pinder SE., Lawrence G., Sawyer E., Kearins O., Ball GR., Tomlinson I., Hanby A., Thomas JSJ., Maxwell AJ., Wallis MG., Dodwell DJ., Sloane Project Steering Group (NHS Prospective Study of Screen-Detected Non-invasive Neoplasias) None.
BACKGROUND: Management of screen-detected ductal carcinoma in situ (DCIS) remains controversial. METHODS: A prospective cohort of patients with DCIS diagnosed through the UK National Health Service Breast Screening Programme (1st April 2003 to 31st March 2012) was linked to national databases and case note review to analyse patterns of care, recurrence and mortality. RESULTS: Screen-detected DCIS in 9938 women, with mean age of 60 years (range 46-87), was treated by mastectomy (2931) or breast conserving surgery (BCS) (7007; 70%). At 64 months median follow-up, 697 (6.8%) had further DCIS or invasive breast cancer after BCS (7.8%) or mastectomy (4.5%) (p