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The phenomenon of aerobic glycolysis observed in cancer cells has remained unexplained. In the May 2007 issue of Cancer Cell, Zhang and colleagues determine that the hypoxia-inducible factor family of transcriptional factors regulate mitochondrial biogenesis through inhibition of C-MYC.

Original publication

DOI

10.1016/j.devcel.2007.05.006

Type

Journal article

Journal

Dev Cell

Publication Date

06/2007

Volume

12

Pages

845 - 846

Keywords

Basic Helix-Loop-Helix Transcription Factors, Energy Metabolism, Humans, Hypoxia-Inducible Factor 1, alpha Subunit, Mitochondria, Neoplasms, Oxygen, Proto-Oncogene Proteins c-myc, Transcription, Genetic, Tumor Suppressor Proteins, Von Hippel-Lindau Tumor Suppressor Protein