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Fourteen patients with advanced breast cancer were treated with the ribonucleotide reductase inhibitor didox 6 g m-2 given by intravenous infusion over 36 h every 3 weeks. None responded and toxicity was minimal. Possibilities for the more effective use of this agent are discussed.


Journal article


Br J Cancer

Publication Date





1187 - 1188


Antimetabolites, Antineoplastic, Breast Neoplasms, Drug Evaluation, Humans, Hydroxamic Acids, Ribonucleotide Reductases