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Topoisomerase II is a key target of many anticancer drugs used to treat lung cancer. We measured the expression of topoisomerase II alpha and beta mRNA's and also the levels of cellular topoisomerase II alpha and beta protein and concluded that topoisomerase II alpha levels are important in cellular resistance to the topoisomerase II inhibitors examined. This can be clearly seen in pairs of matched cell lines. However, when looking at a panel of cell lines with a range of histological types the importance of the enzyme can be masked by other cellular characteristics such as repair and detoxification mechanisms.

Type

Journal article

Journal

Anticancer Res

Publication Date

07/1996

Volume

16

Pages

1603 - 1610

Keywords

Amsacrine, Antineoplastic Agents, Blotting, Western, Cell Line, Chlorambucil, DNA Topoisomerases, Type II, Doxorubicin, Drug Resistance, Neoplasm, Enzyme Inhibitors, Etoposide, Humans, Lung Neoplasms, Mitoxantrone, RNA, Messenger, Transcription, Genetic, Tumor Cells, Cultured