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Non-coding regions of the human genome contain vast regulatory potential that contributes to the coordination of gene expression. Indeed, regulatory elements can reside large genomic distances from the promoters of genes they control. Here we describe approaches recently used to identify functional elements within the complex CFTR locus.

Original publication

DOI

10.4161/trns.2.1.13693

Type

Journal article

Journal

Transcription

Publication Date

01/2011

Volume

2

Pages

23 - 27

Keywords

CFTR, DNase I hypersensitivity, DNase-chip, chromosome conformation capture (3C), tissue-specific enhancers, Binding Sites, Blotting, Southern, Chromatin, Chromatin Immunoprecipitation, Cystic Fibrosis Transmembrane Conductance Regulator, DNA, Deoxyribonuclease I, Gene Expression Regulation, Genome, Human, Genomics, Humans, Insulator Elements, Introns, Promoter Regions, Genetic, Regulatory Sequences, Nucleic Acid, Transcription Factors