Contact information
mark.middleton@oncology.ox.ac.uk
+44 (0)1865 617331 (PA)
Taryn Hastings
PAtoMarkMiddleton@oncology.ox.ac.uk
Research groups
Research Themes
Genome Integrity & Epigenetics (Collaborator)
Immunology (Collaborator)
COLLABORATORS
- Professor Xin Lu, Ludwig Institute Oxford Branch – immune responses in oesophageal cancer
- Professor Niki Sibson, Department of Oncology – TNF muteins as cancer treatments
- Professor Julia Newton-Bishop, University of Leeds – patient driven melanoma cohort
Mark Middleton
Head, Department of Oncology
- Professor of Experimental Cancer Medicine
- Consultant Medical Oncologist, Oxford Cancer and Haematology Centre
Research Summary
I’m interested in the development of new drugs to treat cancer, principally immunotherapies. To achieve this I work with scientists and drug companies to validate drug targets, optimise candidate molecules and design both pre-clinical testing programmes and early clinical trials, with the aim of bringing these trials to patients here in Oxford.
Biography
Mark trained in Medicine at the Universities of Cambridge and Oxford, and in Oncology at the Christie Hospital and University of Manchester. His clinical and research interests are in new cancer drug development and the treatment of upper GI cancers and melanoma. He has been Chief or Principal Investigator on over 100 trials and is closely involved in the development of new therapies including DNA repair, immune checkpoint and kinase inhibitors, ImmTACs and oncolytic viruses. Mark is Director of the CRUK Oxford Centre and Head of Oncology at the University of Oxford, where he founded the Early Phase Clinical Trials Unit.
GROUP MEMBERS
I deliver trials through the Early Phase Clinical Trials Unit and with the Oncology Clinical Trials Office. My translational research is conducted through collaborations and I co-supervise several students:
- Rebecca Wiltshire (with Dr Michele Peters)
- Alina Popa (with Immunocore)
- Fei Gao (with Profs Graham Ogg and Tao Dong)
- Rob Watson (with Dr Ben Fairfax).
Group Alumni & Next Destinations
- Nicholas Coupe, DPhil Student (with V Macaulay) – Consultant Medical Oncologist, OUH
- Ioannis Karydis, DPhil Student (with V Cerundolo) – Senior Lecturer, University of Southampton
- Richard Owen, DPhil Student (with X Lu) – Academic Surgeon, OUH and University of Oxford
- Jonathon Kwok, DPhil Student (with P Klenerman) – CEO, Infinitopes
- Vinton Cheng, DPhil Student with (N Sibson – Academic Clinical Lecturer, University of Leeds
Recent publications
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Journal article
Jackson A. et al, (2024), Lancet Oncol, 25, 1476 - 1486
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Journal article
Scanlon E. et al, (2024), ESMO Open, 9
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Preprint
Milotay G. et al, (2024)
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Journal article
Weber JS. et al, (2024), J Clin Oncol
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A retrospective analysis of the validity and timeliness of cancer diagnosis data collected during a prospective cohort study and reported by the English and Welsh cancer registries
Journal article
Jackson A. et al, (2024), The Lancet Oncology