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Research Theme

Madalena Tarsounas

Professor of Molecular & Cell Biology

  • CRUK Senior Group Leader - Oxford Institute for Radiation Oncology

Research Summary

Our research is focused on gaining a greater understanding of how homologous recombination (HR), the major DNA repair pathway in mammalian cells, helps to prevent genomic instability, the underlying mechanism of many cancers. In particular, we study how tumor cells lacking BRCA1 or BRCA2 gene function differ from normal cells in their responses to exogenous damage induced by ionizing radiation, as well as to cell-intrinsic challenges that arise during DNA replication.

Biography

Madalena Tarsounas is Professor of Molecular and Cell Biology (since 2015) and a CRUK Senior Group Leader within the Oxford Institute for Radiation Oncology (since 2006).

After obtaining her PhD at York University in Toronto, Canada (1999), she undertook postdoctoral training at the CRUK Clare Hall Laboratories of the London Research Institute (1999-2005), where she held postdoctoral fellowships from the European Molecular Biology Organization (EMBO) and the Breast Cancer Campaign. In 2010, she was elected EMBO Young Investigator. In 2011 Madalena has initiated the EMBO Conference Series on ‘DNA damage responses in cell physiology and disease’ held in Cape Sounio, Greece, which has since become a biennial international event. 

GROUP MEMBERS

Hugo Benainous, DPhil student
Rebecca Dagg, Postdoctoral Researcher
Florian Groelly, DPhil student
Giuliana de Gregoriis, Postdoctoral Researcher
Timo Reislander, DPhil student
Angelina Zheleva, Postdoctoral Researcher

GROUP ALUMNI & NEXT DESTINATIONS

Dr. Alex Zelensky (Feb. 2006 – Jan. 2008) CRUK-funded postdoctoral fellow - Postdoctoral fellow in the lab of Dr. Ronal Kanaar, Rotterdam, Netherlands
Dr. Chunyan Liao (March 2008 - March 2010) CRUK-funded postdoctoral fellow - Research assistant in the lab of Prof. Sherif El-Khamisy, University of Sheffield, UK
Kerstin Klare (Oct. 2010 – Aug. 2011) MRes student jointly with Prof. George Iliakis (University of Essen, Germany) - Post-doctoral fellow at the Max Planck Institute, Dortmund, Germany
Maria Thanasoula (Oct. 2007 – Oct. 2011) CRUK-funded DPhil student - Postdoctoral fellow in Prof. Andrea Musacchio’s lab at the Max Planck Institute, Dortmund, Germany
Dr. Jose Escandell (April 2008 – Nov. 2012) CRUK-funded postdoctoral fellow - Postdoctoral fellow at the Gulbenkian Institute, Lisbon, Portugal
Dr. Panagiotis Kotsantis (April 2011 – Oct. 2012) CRUK-funded postdoctoral fellow - Postdoctoral fellow at The Crick Institute, London UK
Ana Rita Carlos (Jan. 2010 – Dec. 2012) DPhil student - Postdoctoral fellow in the lab of Dr. Miguel Soares, Gulbenkian Institute, Lisbon, Portugal
Dr. Natsuko Suwaki (August 2010 – Feb. 2013) CRUK-funded postdoctoral fellow - Glaxo SmithKline, London, UK
Dr. Panagiotis Kotsantis (April 2011 – Oct. 2012) CRUK-funded postdoctoral fellow - Postdoctoral fellow at Crick Institute, London
Eliana Tacconi (Oct. 2012 – Nov. 2015) MRC-funded DPhil student - Medical student, University of Oxford
Mathilde de Jong (Oct. 2013 – August 2014) MRes. student co-supervised with Dr. Geert Koops (Utrecht University) - PhD student,  University Medical Centre Groningen.
Dr. Cecilia Folio (Feb. 2013 - Oct. 2016) CRUK-funded postdoctoral fellow - Research scientist at Adaptimmune, Abingdon UK
Dr. Johanna Michl (Oct. 2014 - June 2017) CRUK-funded postdoctoral fellow - Postdoctoral fellow at University of Oxford
Jutta Zimmer (Oct. 2014 – Oct. 2017) CRUK-funded DPhil student, University of Oxford - CRUK funding administrative team, London
Gijs Zonderland (Oct. 2015 – Dec. 2017) CRUK-funded MRes student - PhD student at University of Copenhagen
Dr. Xianning Lai (May 2013 - July 2017) CRUK-funded postdoctoral fellow - Postdoctoral fellow at National University of Singapore, Cancer Science Institute of Singapore
Sophie Badie (Jan. 2006 - Oct. 2018) laboratory technician - Adaptimmune, Abingdon, UK

Recent publications

More publications