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Shazia Irshad

Contact information

Email
shazia.irshad@ndcls.ox.ac.uk

Collaborators

Ian Tomlinson

Professor of Cancer Genetics
Walter Bodmer

Professor of Genetics

Shazia Irshad

PhD

Senior Research Associate

Recent publications

Epithelial GREMLIN1 disrupts intestinal epithelial-mesenchymal crosstalk to induce a wnt-dependent ectopic stem cell niche through stromal remodelling.
Journal article

Mulholland EJ. et al, (2025), Nat Commun, 16
GREMLIN1 disrupts intestinal epithelial-mesenchymal crosstalk to induce a wnt-dependent ectopic stem cell niche via stromal remodelling
Preprint

Mulholland EJ. et al, (2024)
Adult stem cell activity in naked mole rats for long-term tissue maintenance
Journal article

IRSHAD S., (2023), Nature Communications
Adult stem cell activity in naked mole rats for long-term tissue maintenance.
Journal article

Montazid S. et al, (2023), Nat Commun, 14
Generation of transplantable and biologically responsive colonic tissue from human induced pluripotent stem cells using a rapid co-differentiation platform
Preprint

Dalleywater W. et al, (2023)
Serum- and Glucocorticoid-induced Kinase Sgk1 Directly Promotes the Differentiation of Colorectal Cancer Cells and Restrains Metastasis.
Journal article

Lee LYW. et al, (2019), Clin Cancer Res, 25, 629 - 640
Bone morphogenetic protein and Notch signalling crosstalk in poor-prognosis, mesenchymal-subtype colorectal cancer.
Journal article

Irshad S. et al, (2017), J Pathol, 242, 178 - 192
WHOLE TRANSCRIPTOME ANALYSIS OF COLON CANCER LYMPH NODE METASTASES REVEALS METASTASIS DRIVER GENES, SIGNATURES AND EFFECT OF LYMPHOID ECOLOGICAL NICHE IMMUNE PROFILE
Conference paper

Lee L. et al, (2017), GUT, 66, A31 - A32
Microenvironmental control of stem cell fate in intestinal homeostasis and disease.
Journal article

Biswas S. et al, (2015), J Pathol, 237, 135 - 145
Microenvironmental control of stem cell fate in intestinal homeostasis and disease
Journal article

Biswas S. et al, (2015), Journal of Pathology, 237, 135 - 145
Erratum: The Brn-3b transcription factor regulates the growth, behavior, and invasiveness of human neuroblastoma cells in vitro and in vivo (Journal of Biological Chemistry (2004) 279 (21617-21627) DOI: 10.1074/jbc.A114.312506)
Journal article

Irshad S. et al, (2015), Journal of Biological Chemistry, 290
Stefan Grimm, 1963-2014, a tragic loss for the scientific community.
Journal article

Mahul-Mellier A-L. et al, (2015), Cell Death Differ, 22
Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche.
Journal article

Davis H. et al, (2015), Nat Med, 21, 62 - 70
Aberrant Epithelial GREM1 Expression Promotes Stem-Cell Plasticity and Ectopic Crypt Formation in the Pathogenesis of Familial and Sporadic Human Polyps
Conference paper

Davis HL. et al, (2014), GASTROENTEROLOGY, 146, S86 - S86
A molecular signature predictive of indolent prostate cancer (Science Translational Medicine (2013) 5, (203er9))
Journal article

Irshad S. et al, (2013), Science Translational Medicine, 5
A molecular signature predictive of indolent prostate cancer.
Journal article

Irshad S. et al, (2013), Sci Transl Med, 5
ERK and AKT signaling drive MED1 overexpression in prostate cancer in association with elevated proliferation and tumorigenicity.
Journal article

Jin F. et al, (2013), Mol Cancer Res, 11, 736 - 747
Modeling prostate cancer in mice: something old, something new, something premalignant, something metastatic.
Journal article

Irshad S. and Abate-Shen C., (2013), Cancer Metastasis Rev, 32, 109 - 122
Isolation of ORCTL3 in a novel genetic screen for tumor-specific apoptosis inducers.
Journal article

Irshad S. et al, (2009), Cell Death Differ, 16, 890 - 898
Proliferation-associated Brn-3b transcription factor can activate cyclin D1 expression in neuroblastoma and breast cancer cells.
Journal article

Budhram-Mahadeo VS. et al, (2008), Oncogene, 27, 145 - 154
The Brn-3b transcription factor regulates the growth, behavior, and invasiveness of human neuroblastoma cells in vitro and in vivo.
Journal article

Irshad S. et al, (2004), J Biol Chem, 279, 21617 - 21627
The Brn-3a POU family transcription factor stimulates p53 gene expression in human and mouse tumour cells.
Journal article

Budhram-Mahadeo V. et al, (2002), Neurosci Lett, 334, 1 - 4

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