Contact information

Email
shazia.irshad@ndcls.ox.ac.uk

Collaborators

Ian Tomlinson

Professor of Cancer Genetics
Walter Bodmer

Professor of Genetics

Shazia Irshad

PhD

Senior Research Associate

Key publications

HIF-1-regulated TPM3 links hypoxia to motility and invasion beyond the hypoxic fraction in triple-negative breast cancer.

Zhou C. et al, (2026), NPJ Breast Cancer

Chromosomal instability shapes the tumor microenvironment of esophageal adenocarcinoma via a cGAS-chemokine-myeloid axis.

Beernaert B. et al, (2026), Sci Adv, 12

Lipid-rich ascites reprograms T cell lipid metabolic transcriptome to drive dysfunction

Wan PK-T. et al, (2026)

High-risk molecular features may eclipse genomic complexity in predicting chronic lymphocytic leukemia outcomes; UK clinical trial insights.

Parker H. et al, (2026), Leukemia

Fully automated volumetry of ventricular subregions on computed tomography using object detection and semantic segmentation.

Da Mutten R. et al, (2026), Neuroimage Rep, 6

Photon FLASH spares radiation-induced changes in cardiac function, remodelling and arrythmia in a preclinical model.

Ghita-Pettigrew M. et al, (2026), Radiother Oncol, 216

HLA Heterozygosity Influences Colorectal Cancer Risk and Survival Outcome.

Tsai Y-Y. et al, (2026), Gastroenterology, 170, 619 - 622

The OligoPanc project: an interdisciplinary expert consensus statement on oligometastatic pancreatic cancer.

Leonhardt C-S. et al, (2026), Lancet Oncol, 27, e141 - e149

DESTINY-Gastric05 phase III trial of first-line trastuzumab deruxtecan, chemotherapy, and pembrolizumab in HER2-positive gastric or gastroesophageal junction cancer

Janjigian YY. et al, (2026), ESMO Gastrointestinal Oncology, 11

A0594 Drug-testing in patient-derived renal cell carcinoma organoids reveals pathways of vulnerability and resistance

Steven M. et al, (2026), European Urology, 89, S1 - S2

The PRAGMATIC pathway - PRostate cancer diAGnosis and MAnagement Triage In Clinical care.

Sharma A. et al, (2026), BJU Int

Protocol of the RADIO-STAR trial: a phase 1 safety and dose finding study of hypofractionated radiotherapy to the stellate ganglia for the treatment of ventricular arrhythmia.

Bussmann BM. et al, (2026), BMJ Open, 16

Is liquid biopsy a cost-effective method to diagnose Burkitt Lymphoma in children and young adults? A health economic evaluation in Tanzania.

Jiang J. et al, (2026), BMC Med

Real-time intraoperative depth estimation in transsphenoidal surgery using deep learning: A feasibility study.

Zanier O. et al, (2026), J Clin Neurosci, 147

Assessing the effects of a 3D pathology tissue-processing workflow on downstream molecular analyses.

Baraznenok E. et al, (2026)

CMS subtypes correlate with complete response in trial of neoadjuvant Galunisertib plus chemoradiation in rectal cancer.

Rajamanickam V. et al, (2026), Transl Oncol, 66

Negative Selection Maintains Grossly Altered but Broadly Stable Karyotypes in Metastatic Colorectal Cancer.

Cross WCH. et al, (2026), Cancer Discov, 16, 218 - 234

Succinate receptor 1 restricts hematopoiesis and prevents acute myeloid leukemia progression.

Cuminetti V. et al, (2026), Nat Commun

Characterisation of bacteria-induced colitis and its modulation by probiotics in naked mole rats: a new mammalian model for acute inflammatory disease.

Hart DW. et al, (2026), J Pathol

Shortened High-dose Palliative Radiotherapy for Lung Cancer (SHiP-Rt): protocol for a single-arm, multicentre, phase II study.

Shrimali RK. et al, (2026), BMJ Open, 16

Bridging the gaps in fibroblast activation protein targeted radionuclide therapy: a translational perspective.

Wu C. et al, (2026), Eur J Nucl Med Mol Imaging

Survival outcomes of ERBB2-amplified metastatic colorectal cancer treated with first-line chemotherapy.

Matsubara Y. et al, (2026), Br J Cancer, 134, 463 - 468

The circulating proteome and cancer risk: a systematic literature review and meta-analysis of 26 prospective studies with genetic validation.

Dillman A. et al, (2026), EBioMedicine, 124

Impact of high-dose vitamin D and calcium carbonate supplementation on bone density in adolescents living with HIV: a randomised, placebo-controlled trial.

Ferrand RA. et al, (2026), Lancet Child Adolesc Health, 10, 111 - 121

Media coverage and PATHFINDER2: hype, simplification, and free advertising.

Turnbull C. et al, (2026), Lancet Oncol, 27, 144 - 145

ESMO Clinical Practice Guideline Express Update on the adoption of physical exercise in patients with localised colon cancer.

Pentheroudakis G. et al, (2026), ESMO Open, 11

Impact and effective management of nausea/vomiting on patients treated with zolbetuximab + chemotherapy: insights from the phase III SPOTLIGHT and GLOW studies.

Shitara K. et al, (2026), ESMO Open, 11

Cumulative Absorbed Dose and Successive Cyclic Reduction in Absorbed Dose Predict Response to 177Lu-DOTATATE in Neuroendocrine Tumors.

Macsuka MJ. et al, (2026), J Nucl Med

Harness Behavioural Analysis for Unpacking the Bio-Interpretability of Pathology Foundation Models

Hu Y. et al, (2026)

Genomic risk model to implement precision prostate cancer screening in clinical care: the ProGRESS study.

Vassy JL. et al, (2026), Nat Cancer

Improved Safety of New MicroRNA-Regulated Oncolytic Coxsackievirus B3 Observed After Intravenous Administration in Colorectal-Tumor-Bearing Mice.

Elsner L. et al, (2026), Viruses, 18

Separate transcription and splicing gene networks are linked and coordinated by the pRb-E2F pathway.

Carr SM. et al, (2026), Nucleic Acids Res, 54

Circulating tumour cells as a window into lethality in prostate cancer.

Abusamra SM. et al, (2026), Nat Rev Urol

Fine-tuning BACH2 dosage balances stemness and effector function to enhance antitumor T cell therapy.

Conti AG. et al, (2026), Nat Immunol

TomoRay cranial: synthesis of cranial CT imaging from biplanar radiographs using a generative adversarial network.

Zanier O. et al, (2026), Eur Radiol

Mixed-model and transcriptome-wide association analyses identify transcription factors and genes associated with colorectal cancer susceptibility.

Chen Z. et al, (2026), Nat Commun, 17

A call to standardize the definition of countries with a high-burden of sickle cell disease

Seabold A. et al, (2026), Journal of Sickle Cell Disease, 3

Promises under pressure: the modest predictive power of polygenic risk scores.

Horton R. et al, (2026), Eur J Hum Genet

High throughput mutational characterization of the GPCR ligand C5a using yeast display and deep sequencing.

Xu Y. et al, (2026), Structure, 34, 184 - 197.e4

Distinct regulatory elements of SLC6A14 expression contribute to modification of cystic fibrosis phenotypes.

Esmaeili M. et al, (2026), Hum Genet, 145

TMEM33 deletion potentiates anti-tumor CD8+ T cell immunity.

Jackson MT. et al, (2026), bioRxiv

Nicotinamide N-Methyl Transferase (NNMT) Sustains Innate Sensitivity to NAMPT Inhibition in YAP-dependent Stem-like/Mesenchymal Prostate Cancer.

Carreira ÁSA. et al, (2026), Int J Biol Sci, 22, 1126 - 1141

Acceptability of a virtual tour for anxiety alleviation in PET-CT - A pilot study.

Barnard MA. et al, (2026), Radiography (Lond), 32

Sigscores: summary scores for molecular signatures in R.

Barberis A. and Buffa FM., (2026), Bioinform Adv, 6

HER2 Protein Overexpression, mRNA Expression, and DNA Amplification Across Solid Tumors: Comparison of Next-Generation Sequencing-Based Assays With Immunohistochemistry.

Nagamine M. et al, (2026), JCO Precis Oncol, 10

Systemic complement protein levels as biomarkers of chemoradiotherapy response in anal squamous cell carcinoma.

Majorova D. et al, (2026), Radiother Oncol, 214

Correction: Preferences for multi-cancer tests (MCTs) in primary care: discrete choice experiments of general practitioners and the general public in England.

Buckell J. et al, (2026), Br J Cancer, 134, 175 - 176

Experimental Cancer Medicine Centre (ECMC) network proposal for a consensus gene panel for pan-cancer sequencing: a Delphi methodology.

Phillips R. et al, (2026), Br J Cancer, 134, 289 - 294

Lactation, tissue-resident immunity, and protection against breast cancer.

Little M. et al, (2026), Trends Immunol, 47, 3 - 5

Quantifying the flash effect and its dependence on average dose rate in vivo for 6 MeV electron and 6 MV photon beams.

Paillas S. et al, (2026), Clin Transl Radiat Oncol, 56

Paclitaxel and rose bengal loaded microbubbles for the ultrasound targeted chemo-sonodynamic therapy of pancreatic cancer.

Wright J. et al, (2026), Eur J Pharm Biopharm, 218

Progression-free survival as a surrogate for overall survival in gastro-esophageal cancer trials with immunotherapy: A meta-analysis.

Leone AG. et al, (2026), Eur J Cancer, 232

Current landscape, successes, and key challenges in cancer vaccine clinical trials across the UK.

Watson RA. et al, (2026), Lancet Oncol, 27, 19 - 22

Diagnostic accuracy of a ‘stage-gated’ approach for reporting prostate screening MRI: “Is less more?”

Thorley N. et al, (2026), European Radiology

Specialised or Generic? Tokenization Choices for Radiology Language Models

Warr H. et al, (2026), Lecture Notes in Computer Science, 16146 LNCS, 62 - 70

Integrating multi-omic datasets investigating stress response biology decodes prostate cancer dynamic disease progression and places IRE1 activity at the epicentre of acquired treatment resistance

Doultsinos D. et al, (2026), CANCER RESEARCH, 86

The Response

Bottini M. et al, (2026), NEUROSURGICAL FOCUS, 60

Abstract PR013: Comprehensive spatial profiling of prostate cancer metastasis: Mapping clonal evolution, microenvironment dynamics, and early metastatic markers

He M. et al, (2026), CANCER RESEARCH, 86, PR13 - PR13

Trifluridine/tipiracil (FTD/TPI) in advanced gastric cancer-a retrospective cohort study providing real-world survival and safety data from the United Kingdom.

Salf J. et al, (2025), J Gastrointest Oncol, 16, 2584 - 2591

Impact of preoperative weight-loss interventions on outcomes after elective non-bariatric surgery: meta-analysis.

Wang D. et al, (2025), BJS Open, 10

Recent publications

Characterisation of bacteria-induced colitis and its modulation by probiotics in naked mole rats: a new mammalian model for acute inflammatory disease.

Hart DW. et al, (2026), J Pathol

Epithelial GREMLIN1 disrupts intestinal epithelial-mesenchymal crosstalk to induce a wnt-dependent ectopic stem cell niche through stromal remodelling.

Mulholland EJ. et al, (2025), Nat Commun, 16

GREMLIN1 disrupts intestinal epithelial-mesenchymal crosstalk to induce a wnt-dependent ectopic stem cell niche via stromal remodelling

Mulholland EJ. et al, (2024)

Adult stem cell activity in naked mole rats for long-term tissue maintenance.

Montazid S. et al, (2023), Nat Commun, 14

Adult stem cell activity in naked mole rats for long-term tissue maintenance

IRSHAD S., (2023), Nature Communications

Generation of transplantable and biologically responsive colonic tissue from human induced pluripotent stem cells using a rapid co-differentiation platform

Dalleywater W. et al, (2023)

Serum- and Glucocorticoid-induced Kinase Sgk1 Directly Promotes the Differentiation of Colorectal Cancer Cells and Restrains Metastasis.

Lee LYW. et al, (2019), Clin Cancer Res, 25, 629 - 640

Bone morphogenetic protein and Notch signalling crosstalk in poor-prognosis, mesenchymal-subtype colorectal cancer.

Irshad S. et al, (2017), J Pathol, 242, 178 - 192

WHOLE TRANSCRIPTOME ANALYSIS OF COLON CANCER LYMPH NODE METASTASES REVEALS METASTASIS DRIVER GENES, SIGNATURES AND EFFECT OF LYMPHOID ECOLOGICAL NICHE IMMUNE PROFILE

Lee L. et al, (2017), GUT, 66, A31 - A32

Microenvironmental control of stem cell fate in intestinal homeostasis and disease.

Biswas S. et al, (2015), J Pathol, 237, 135 - 145

Microenvironmental control of stem cell fate in intestinal homeostasis and disease

Biswas S. et al, (2015), Journal of Pathology, 237, 135 - 145

Erratum: The Brn-3b transcription factor regulates the growth, behavior, and invasiveness of human neuroblastoma cells in vitro and in vivo (Journal of Biological Chemistry (2004) 279 (21617-21627) DOI: 10.1074/jbc.A114.312506)

Irshad S. et al, (2015), Journal of Biological Chemistry, 290

Stefan Grimm, 1963-2014, a tragic loss for the scientific community.

Mahul-Mellier A-L. et al, (2015), Cell Death Differ, 22

Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche.

Davis H. et al, (2015), Nat Med, 21, 62 - 70

Aberrant Epithelial GREM1 Expression Promotes Stem-Cell Plasticity and Ectopic Crypt Formation in the Pathogenesis of Familial and Sporadic Human Polyps

Davis HL. et al, (2014), GASTROENTEROLOGY, 146, S86 - S86

A molecular signature predictive of indolent prostate cancer (Science Translational Medicine (2013) 5, (203er9))

Irshad S. et al, (2013), Science Translational Medicine, 5

A molecular signature predictive of indolent prostate cancer.

Irshad S. et al, (2013), Sci Transl Med, 5

ERK and AKT signaling drive MED1 overexpression in prostate cancer in association with elevated proliferation and tumorigenicity.

Jin F. et al, (2013), Mol Cancer Res, 11, 736 - 747

Modeling prostate cancer in mice: something old, something new, something premalignant, something metastatic.

Irshad S. and Abate-Shen C., (2013), Cancer Metastasis Rev, 32, 109 - 122

Isolation of ORCTL3 in a novel genetic screen for tumor-specific apoptosis inducers.

Irshad S. et al, (2009), Cell Death Differ, 16, 890 - 898

Proliferation-associated Brn-3b transcription factor can activate cyclin D1 expression in neuroblastoma and breast cancer cells.

Budhram-Mahadeo VS. et al, (2008), Oncogene, 27, 145 - 154

The Brn-3b transcription factor regulates the growth, behavior, and invasiveness of human neuroblastoma cells in vitro and in vivo.

Irshad S. et al, (2004), J Biol Chem, 279, 21617 - 21627

The Brn-3a POU family transcription factor stimulates p53 gene expression in human and mouse tumour cells.

Budhram-Mahadeo V. et al, (2002), Neurosci Lett, 334, 1 - 4

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Contact information

Collaborators

Shazia Irshad

Key publications

Recent publications