Contact information
Collaborators
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Ian Tomlinson
Professor of Cancer Genetics
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Walter Bodmer
Professor of Genetics
Shazia Irshad
PhD
Senior Research Associate
Key publications
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Adult stem cell activity in naked mole rats for long-term tissue maintenance
Journal article
IRSHAD S., (2023), Nature Communications
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Serum- and Glucocorticoid-induced Kinase Sgk1 Directly Promotes the Differentiation of Colorectal Cancer Cells and Restrains Metastasis.
Journal article
Lee LYW. et al, (2019), Clin Cancer Res, 25, 629 - 640
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Bone morphogenetic protein and Notch signalling crosstalk in poor-prognosis, mesenchymal-subtype colorectal cancer.
Journal article
Irshad S. et al, (2017), J Pathol, 242, 178 - 192
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Microenvironmental control of stem cell fate in intestinal homeostasis and disease
Journal article
Biswas S. et al, (2015), Journal of Pathology, 237, 135 - 145
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Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche.
Journal article
Davis H. et al, (2015), Nat Med, 21, 62 - 70
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Modeling prostate cancer in mice: something old, something new, something premalignant, something metastatic.
Journal article
Irshad S. and Abate-Shen C., (2013), Cancer Metastasis Rev, 32, 109 - 122
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A molecular signature predictive of indolent prostate cancer.
Journal article
Irshad S. et al, (2013), Sci Transl Med, 5
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Isolation of ORCTL3 in a novel genetic screen for tumor-specific apoptosis inducers.
Journal article
Irshad S. et al, (2009), Cell Death Differ, 16, 890 - 898
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Proliferation-associated Brn-3b transcription factor can activate cyclin D1 expression in neuroblastoma and breast cancer cells.
Journal article
Budhram-Mahadeo VS. et al, (2008), Oncogene, 27, 145 - 154
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The Brn-3b transcription factor regulates the growth, behavior, and invasiveness of human neuroblastoma cells in vitro and in vivo.
Journal article
Irshad S. et al, (2004), J Biol Chem, 279, 21617 - 21627
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The Brn-3a POU family transcription factor stimulates p53 gene expression in human and mouse tumour cells.
Journal article
Budhram-Mahadeo V. et al, (2002), Neurosci Lett, 334, 1 - 4
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Microenvironmental control of stem cell fate in intestinal homeostasis and disease.
Journal article
Biswas S. et al, (2015), J Pathol, 237, 135 - 145