Contact information
Collaborators
Head, Department of Oncology
Professor of Cancer Medicine, RDM
Professor of Cancer Genetics
Honorary Clinical Researcher
Associate Professor, NDPCH
Yoshiaki Nakamura
Royal Society Wolfson Visiting Fellow
Biography
Dr Yoshiaki Nakamura trained in Medicine at Osaka University and obtained his PhD from Keio University. His clinical and research interests focus on gastrointestinal cancer, liquid biopsy, precision oncology, and early cancer detection. He has led multiple nationwide studies, including SCRUM-Japan and CIRCULATE-Japan, pioneering the clinical use of circulating tumour DNA (ctDNA) for precision medicine and minimal residual disease (MRD) monitoring. Dr Nakamura has served as Principal Investigator on numerous clinical and translational trials that contributed to new drug and companion diagnostic approvals in Japan.
Research Summary
Dr Nakamura’s research focuses on translating liquid biopsy technologies into clinical practice for precision oncology and early cancer detection. His work integrates circulating tumour DNA (ctDNA) analysis for minimal residual disease (MRD) and multi-cancer early detection (MCED) with artificial intelligence-driven histopathological and genomic modelling. Dr Nakamura aims to build large-scale, data-driven frameworks that bridge clinical trials, molecular profiling, and digital health innovation.
Key publications
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ctDNA-based molecular residual disease and survival in resectable colorectal cancer
Journal article
Nakamura Y. et al, (2024), Nature Medicine, 30, 3272 - 3283
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Tucatinib and Trastuzumab for Previously Treated Human Epidermal Growth Factor Receptor 2–Positive Metastatic Biliary Tract Cancer (SGNTUC-019): A Phase II Basket Study
Journal article
Nakamura Y. et al, (2023), Journal of Clinical Oncology, 41, 5569 - 5578
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Clinical utility of circulating tumor DNA sequencing in advanced gastrointestinal cancer: SCRUM-Japan GI-SCREEN and GOZILA studies.
Journal article
Nakamura Y. et al, (2020), Nature medicine, 26, 1859 - 1864
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Targeted therapy guided by circulating tumor DNA analysis in advanced gastrointestinal tumors.
Journal article
Nakamura Y. et al, (2025), Nature medicine, 31, 165 - 175
Recent publications
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Impact of Human Epidermal Growth Factor Receptor 2 in Patients With Metastatic Colorectal Cancer Treated With Chemotherapy Plus Bevacizumab or Anti-EGFRs: Exploratory Analysis of Eight Randomized Trials
Journal article
Germani MM. et al, (2025), Journal of Clinical Oncology, 43, 3184 - 3197
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Clinical Significance of Extrachromosomal DNA in
FGFR2
-Amplified Gastric Cancer: Therapeutic Implications From Clinical Experience
Journal article
Aoki Y. et al, (2025), JCO Precision Oncology
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HIBRID: histology-based risk-stratification with deep learning and ctDNA in colorectal cancer.
Journal article
Loeffler CML. et al, (2025), Nature communications, 16
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Landscape Analysis of CLDN18 Expression and Isoform Distribution in Solid Tumors: Insights From MONSTAR‐SCREEN‐2 Study
Journal article
Hashimoto T. et al, (2025), Cancer Science, 116, 2218 - 2231
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Prognostic Indicators of Preoperative Fluorouracil, Leucovorin, Oxaliplatin, and Docetaxel Efficacy in Locally Advanced Gastroesophageal and Gastric Cancer: Integrating Biomarker Analysis and Clinicopathological Factors.
Journal article
Jubashi A. et al, (2025), JCO precision oncology, 9






