Contact information
Collaborators
Head, Department of Oncology
Professor of Cancer Medicine, RDM
Professor of Cancer Genetics
Honorary Clinical Researcher
Associate Professor, NDPCH
Yoshiaki Nakamura
Royal Society Wolfson Visiting Fellow
Biography
Dr Yoshiaki Nakamura trained in Medicine at Osaka University and obtained his PhD from Keio University. His clinical and research interests focus on gastrointestinal cancer, liquid biopsy, precision oncology, and early cancer detection. He has led multiple nationwide studies, including SCRUM-Japan and CIRCULATE-Japan, pioneering the clinical use of circulating tumour DNA (ctDNA) for precision medicine and minimal residual disease (MRD) monitoring. Dr Nakamura has served as Principal Investigator on numerous clinical and translational trials that contributed to new drug and companion diagnostic approvals in Japan.
Research Summary
Dr Nakamura’s research focuses on translating liquid biopsy technologies into clinical practice for precision oncology and early cancer detection. His work integrates circulating tumour DNA (ctDNA) analysis for minimal residual disease (MRD) and multi-cancer early detection (MCED) with artificial intelligence-driven histopathological and genomic modelling. Dr Nakamura aims to build large-scale, data-driven frameworks that bridge clinical trials, molecular profiling, and digital health innovation.
Key publications
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ctDNA-based molecular residual disease and survival in resectable colorectal cancer.
Journal article
Nakamura Y. et al, (2024), Nat Med, 30, 3272 - 3283
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Tucatinib and Trastuzumab for Previously Treated Human Epidermal Growth Factor Receptor 2-Positive Metastatic Biliary Tract Cancer (SGNTUC-019): A Phase II Basket Study.
Journal article
Nakamura Y. et al, (2023), J Clin Oncol, 41, 5569 - 5578
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Clinical utility of circulating tumor DNA sequencing in advanced gastrointestinal cancer: SCRUM-Japan GI-SCREEN and GOZILA studies.
Journal article
Nakamura Y. et al, (2020), Nat Med, 26, 1859 - 1864
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Targeted therapy guided by circulating tumor DNA analysis in advanced gastrointestinal tumors.
Journal article
Nakamura Y. et al, (2025), Nat Med, 31, 165 - 175
Recent publications
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Survival outcomes of ERBB2-amplified metastatic colorectal cancer treated with first-line chemotherapy.
Journal article
Matsubara Y. et al, (2025), Br J Cancer
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A multicenter phase II study of eribulin for BRAF V600E mutant metastatic colorectal cancer: the BRAVERY study (EPOC1701)
Journal article
Masuishi T. et al, (2025), ESMO Open, 10
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Impact of Human Epidermal Growth Factor Receptor 2 in Patients With Metastatic Colorectal Cancer Treated With Chemotherapy Plus Bevacizumab or Anti-EGFRs: Exploratory Analysis of Eight Randomized Trials.
Journal article
Germani MM. et al, (2025), J Clin Oncol, 43, 3184 - 3197
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HIBRID: histology-based risk-stratification with deep learning and ctDNA in colorectal cancer.
Journal article
Loeffler CML. et al, (2025), Nat Commun, 16
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Clinical Significance of Extrachromosomal DNA in FGFR2-Amplified Gastric Cancer: Therapeutic Implications From Clinical Experience.
Journal article
Aoki Y. et al, (2025), JCO Precis Oncol, 9






