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The alignment of the 2-picoline ligand within the major groove contributes to the formation of a highly stereoselective GG intrastrand bischelate between the new anticancer drug cis-[PtCl2(NH3)(2-picoline)] and a 14-mer DNA duplex (see schematic representation).

Original publication

DOI

10.1002/(SICI)1521-3773(19990712)38:13/14<2060::AID-ANIE2060>3.0.CO;2-J

Type

Journal article

Journal

Angewandte Chemie - International Edition

Publication Date

12/07/1999

Volume

38

Pages

2060 - 2063