A new platinum anticancer drug forms a highly stereoselective adduct with duplex DNA
Chen Y., Parkinson JA., Guo Z., Brown T., Sadler PJ.
The alignment of the 2-picoline ligand within the major groove contributes to the formation of a highly stereoselective GG intrastrand bischelate between the new anticancer drug cis-[PtCl2(NH3)(2-picoline)] and a 14-mer DNA duplex (see schematic representation).