Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

In the past decade gold nanoparticle-nucleic acid conjugates became progressively important for biomedical applications. Fluorophores attached to nucleic acid-gold nanoparticle conjugates have opened up a new era of biological sensing. The most promising advancement in this field was the invention of the so-called 'nano-flare' systems. These systems are capable of detecting specific endocellular targets such as mRNAs, microRNAs or small molecules in real time. In this minireview, we discuss the current progress in the field of DNA-nanoparticles as sensors, their properties, stability, cellular uptake and cytotoxicity.

Original publication

DOI

10.1039/c3nr03707j

Type

Journal article

Journal

Nanoscale

Publication Date

21/10/2013

Volume

5

Pages

9503 - 9510

Keywords

Biosensing Techniques, Cell Survival, DNA, Fluorescent Dyes, Gold, Humans, Metal Nanoparticles, Microscopy, Fluorescence, Neoplasms, Nucleic Acid Hybridization