Contact information
hena.khalique@oncology.ox.ac.uk
khaliquehena@gmail.com
01865 617041
01865 617042
Research groups
Hena Khalique
MSc, PhD
Postdoctoral Researcher
Oncolytic HSV-1-mediated virotherapy, T cell immunotherapy, Cancer Biology
Research Summary
In my research I am trying to turn the cold suppressive environment of tumour to hot by activating tumour resident T cells. For this, I have constructed a Bi-specific T cells engager (BiTE) which recognizes target cells and T cells and crosslinks them in a ‘pseudo-synapse’. Binding of multiple BiTEs activates T cells and kills target cells.
I am planning to use these agents in combination with oncolytic Herpes Simplex Virus-1 (oHSV-1) to trigger diverse innate immune pathways. This strategy will provide cancer selectivity and prevent ‘on-target off-tumour’ toxicities.
Biography
Hena post-graduated in Biochemistry at the Hamdard University, India which she followed with work at National Brain Research Centre, India. Her research was focused on growth factors mediated protection of human neurons against HIV/AIDS-drug abuse cases. She completed her PhD at Universidad Autonoma de Madrid, Spain. Her thesis was focused on the HSV-1 lytic-latent transition by testing artificial control over ICP0 transcription. In 2017, Hena joined Prof. Leonard Seymour’s group as a postdoctoral researcher in Department of Oncology, University of Oxford.
Collaborators
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Arthur Dyer
Laboratory Manager
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Kerry Fisher
Associate Professor
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Len Seymour
Professor of Gene Therapies
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Shisong Jiang
Associate Professor/ Senior Industrial Fellow
Recent publications
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Journal article
Baugh R. et al, (2020), Cancers (Basel), 12
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Journal article
Dyer A. et al, (2019), Cancer Gene Ther, 26, 59 - 73
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Journal article
Ventosa M. et al, (2017), Gene Ther, 24, 433 - 440
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Journal article
Khalique H. et al, (2016), J Gene Med, 18, 302 - 311
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Journal article
García-Escudero V. et al, (2015), J Cell Mol Med, 19, 1284 - 1295
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Biosafety of gene therapy vectors derived from herpes simplex virus type 1.
Journal article
Lim F. et al, (2013), Curr Gene Ther, 13, 478 - 491
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Gene Therapy of Friedreich is Ataxia: Generation of Recombinant Herpesvirus
Conference paper
Ventosa M. et al, (2013), HUMAN GENE THERAPY, 24, A77 - A78
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Replication-Inducible HSV-1 Vectors: Construction and Application in Gene Therapy
Conference paper
Khalique H. and Lim F., (2013), HUMAN GENE THERAPY, 24, A77 - A77
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Journal article
Koechling T. et al, (2011), J Neurosci Methods, 201, 346 - 354